Seminar at SDU: Philip Hougaard, Survival of Danish twins born 1870-2000

Survival of Danish twins born 1870-2000

Speaker: Professor Philip Hougaard (Lundbeck and SDU).

The background for this talk is that Philip Hougaard will present this project as a contributed paper at a scientific conference. To prepare for this, this longer version is presented at SDU. The actual content will be close to an earlier presentation at SDU (September 2022)

Abstract

Hougaard, Harvald and Holm (1992, Journal of the American Statistical Association, 87, 17-24) used frailty models to consider the survival of same-sex Danish twins born between 1881-1930 with follow-up until 1980 for twins, where both were alive at age 15. That dataset included around 9000 pairs of twins. This presentation gives an update to that analysis. For the birth cohorts 1870-1930, same-sex twins, where both were alive at age 6, are considered. For the birth cohorts 1931-2000, all twins are included. Follow-up is to 2022. This dataset includes around 50000 pairs of twins. The updated dataset has several advantages compared to the old. It is larger in several dimensions (such as earlier as well as later cohorts, longer follow-up, including also opposite-sex pairs and starting observation earlier in life). This, of course, allows for better precision but probably more interesting, it allows for studying time-trends. Furthermore, it is possible to discuss the appropriateness of shared frailty models for studying this problem.

Key words: frailty models; multivariate survival

Joint project with Jacob v. B. Hjelmborg and The Danish Twin Research Center, SDU.

Time: Wednesday November 20th at 13.15-14.00.

Location: Biostat meeting room, OD SUN M-1.21 (V14-700b-1).

SDU Maps: https://clients.mapsindoors.com/sdu/573f26e4bc1f571b08094312/details/a2db215f76644220ace17758

Online: A link can be sent upon request to jhjelmborg@health.sdu.dk