Ph.D. Scholarship between H. Lundbeck A/S and Section of Biostatistics, University of Copenhagen
This scholarship runs for three years as a joint project between Lundbeck and University of Copenhagen. The purpose is to develop and implement statistical methods based on modern causal inference methods.
The purpose of this project is to estimate the interdependence between two or more processes of correlated domains (such as patient-reported and/or clinician-rated depression, cognition and personal functioning) while taking time varying confounders (most notably treatment) into account, as well as to estimate the effect of these time varying confounders, thus ensuring more correct inference regarding the effect of treatment as well as the effect of the time varying processes. To achieve this, new statistical methodology will be motivated by and tried out on one or more of Lundbeck’s observational studies in populations of patients suffering from a psychiatric disease such as depression.
This project aims at clarifying the viability of causal inference as a tool for statistical inference and evaluation of observational longitudinal studies with multiple domains. The implementation of such statistical methodology in Lundbeck is a success criterion for the project. More specifically, the following questions will, by the use of different methods based on causal inference modeling, be answered: 1) Do cognition scores at early time points predict later depression scores, and vice versa? A. What is the role of time-varying covariates in this prediction and, in particular, what is the role of treatment? B. What is the role of baseline covariates in this prediction? 2) How do we in a mathematically sound and clinically relevant way estimate differences between treatment effects?
You must have a background in Statistics at the level of a Master’s / cand.scient. degree. Experience with SAS or R is a necessity, and any prior knowledge about causal inference will be an advantage as will any other experience working with statistics.
Salary and employment
Your salary is set in accordance with the Ministry of Finance’s collective agreement with the Danish Confederation of Professional Associations (AC) concerning Ph.D. students. The actual level will depend on your experience. About 2/3 of the Scholarship is paid by InnovationsFonden, and about 1/3 by Lundbeck.
Your main supervisor will be Professor Torben Martinussen, Section of Biostatistics, University of Copenhagen, Øster Farimagsgade 5B, 1014 Copenhagen K, and Lead Specialist Klaus Groes Larsen, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, will be your co-supervisor. Your working place will be both University of Copenhagen and Lundbeck, and you will have the opportunity to visit a foreign University during the Scholarship.
Please note that the position is conditional on successful enrolment as a Ph.D. student at the Graduate School of Health and Medical Sciences at the University of Copenhagen.
Lundbeck is a global pharmaceutical company highly committed to improving the quality of life in people living with psychiatric and neurological disorders. For this purpose, Lundbeck is engaged in the research, development, production, marketing and sale of pharmaceuticals across the world. The company’s products are targeted at disease areas such as depression, schizophrenia, Parkinson’s disease and Alzheimer’s disease. Please visit www.lundbeck.com for more information